![]() ![]() 11 metabolic pathways are involved in the therapeutic effect of DBT in vivo S-adenosyl-L-methionine, glycine, L-cysteine, arachidonic acid (AA) and phosphatidylcholine(PC) were screened as hub metabolites in APH-and CTX-induced anaemia. The results shown DBT effectively treated anaemia in vivo. ![]() The gene enrichment analysis was used to analyse the relationship between proteins based on the relevant genetic similarity by ClueGO. Using the Cytoscape 3.2.1 to establish a phytochemical component-target protein interaction network and establish a component, protein and hub metabolite protein-protein interaction (PPI) network and merging the three PPI networks basing on BisoGenet. The TCMSP, ChemMapper and STITCH databases were used to predict the protein targets of DBT. Anaemia disease-related protein target and compound of DBT databases were constructed. A metabolomics approach using Liquid Chromatography-Quadrupole-Time-of-Flight/Mass Spectrometry (LC/Q-TOFMS) was developed to perform the plasma metabolic profiling analysis and differential metabolites were screened according to the multivariate statistical analysis comparing the NC and BD groups, and the hub metabolites were outliers with high scores of the centrality indices. kg -1), and blood deficiency (BD) (Cyclophosphamide (APH)-and Cyclophosphamide(CTX)-induced anaemia).Sprague-Dawley(SD) rats were randomly divided into 3 groups including control (NC, Saline), the DBT (at a dose of 8.10 g Exploring new ways of treatment with DBT is useful. Mechanism of DBT action is wide ranging and unclear. Danggui Buxue Tang (DBT) is a famous Chinese medicinal decoction. ![]()
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